Combining alcohol and over-the-counter drugs: Question Combining alcohol and over-the-counter drugs: Answers Can be dangerous. Causes the side effects of both substances to cancel out. Will not affect your riding abilities. Is encouraged. Explanation Many drugs, including prescription and over-the-counter medications, can impair your ability to ride safely. Some medications become even more dangerous when combined with alcohol. This questions appears in the following tests: Connecticut Motorcycle Practice Test 11